We have built a lot of "Cross Ram " induction engines over the years, all for what would now be considered Historic racers. That in itself should tell the story, they don't flow enough air to make "modern" horse power.
Leaving the "look" aside, if you consider the length of the runner as a restriction and the point at which the runners cross as a huge restriction then you are always going to be up against it. We have found because of the length of the runners and small cross section that cam choice becomes super critical.
Small blocks particularly don't have enough room to package everything without compromising the runners. We have built several Bizzarinnis with crossover 327s with both Campagnolo and Moon intakes with 45 and 50 DCOEs, they make great torque for a small engine and original style heads but they only had about 300 HP in their day so air flow didn't really come into it. Surtees built some stroked 327s with something like 55mm Webers and a most peculiar cross over manifold for his T70 but they wouldn't breath. Similarly Allan Smith built some trick looking cross over F5000 engines with DFV style slide throttles, they were " sort of " OK and did produce plenty of torque but as soon as head technology took off they became obsolete very quickly. We have tried them on mildish Brodix heads and they're hopless.
I think you would need a VERY good reason to consider a crossover because from a power point of view you will have to work hard.
Mike
PS. I actually had one of those 413 Cross Ram Chrysler engines in a stock car back in the 60's and apart from being a sales gimmick for the 300E were "tuned" to produce maximum torque at 2500 rpm !