If you're doing anything high speed the plug type puncture repair (including Safety Seal) is probably not the best.
Tires are comprised of steel belts which are a continuous woven surface. A hole compromises the structure and strength of that surface. A small hole from a nail doesn't spread the weave far enough to matter. But the plug repair starts with a reamer which enlarges the hole and the plug keeps it enlarged. Probably why MOT doesn't allow them.
At US speed limits it's probably not going to be an issue with a high speed rated tire. But anything approaching the tires limit is going to be taking a chance.
++++++++++++++++++++++++
The tire inflator cans are OK but there is one thing you have to watch out for. Some of the cheaper variations use, believe it or not, a hydrogen propellant. Needless to say this can be dangerous and I'm not sure why they haven't been banned in the US.
What has happened is that someone fills the tire with the hydrogen inflator and then takes it in for repair. The technician using the plug method reams the puncture with his steel reamer and it strikes a spark on the steel belts and explodes the tire resulting in cases of serious maiming.
This actually happened to a tech just down the street from were I used to work years ago and more recently I found a can of hydrogen type inflator in a trade-in used car, so I know their still out there.
Another problem is obvious in that the can stored in the car is like a miniature bomb.
a Google search shows this article from Bentley Publishers
http://www.bentleypublishers.com/tech/audi/audi.warnings.cautions.htm
"Some aerosol tire inflators are highly flammable. Be extremely cautious when repairing a tire that may have been inflated using an aerosol tire inflator. Keep sparks, open flame or other sources of ignition away from the tire repair area. Inflate and deflate the tire at least four times before breaking the bead from the rim. Completely remove the tire from the rim before attempting any repair."
Most of the tire inflator cans are non-flammable so read the label before purchase.