Hi Vaughn,
One thing I would mention is that many plexi windscreens I have seen have been installed by first creating a hole of that is smaller than the head of the screw you plan to use, but large enough to allow you to install a nylon bushing in the hole in the plexi and have the screw pass through the nylon bushing.
Ideally, the bushing is slightly thicker (i.e. taller) than the plexi, and for a GT40 rear window, if used in conjunction with a medium density foam gasket tape around the perimeter, the windshield is allowed a little room to move around a little without inducing stress on what would normally be small holes in the plexi (and it eliminates direct contact from the sharp threads of the fastener on the edge of the holes, like Chris mentioned above).
You can pick up these nylon bushing at any ace hardware store although you will probably have to cut them to length and possibly drill them to accept your fastener of choice.
Best Regards,
Al