Hmmm. I'm not familiar with that Holley system, but if it is injected (and from the name, it sounds like it might be), I could see that there could be a problem because of the higher pressures. And if the pump is in the tank, I could see a problem. I think the failure modes in my system are not so bad, assuming the line were to fail. Since the pump is on the engine, a broken line would be like drinking through a straw with a hole in it, and the engine would likely just die. If the hole was below the tank, it would leak gasoline but wouldn't spew it because there is no pump pushing it from the tank. A leak above the fuel tank really wouldn't leak at all I don't think - the fuel in the line should just drain back into the tank.
btw, all of the connections are AN- fittings. No clamps. Body flex would seem to be the only thing that would put stress on the tubing. Plus, the line is plenty cheap and easy to route, so can be changed every two years or so whether it needs it or not just to be safe. I don't think there's a problem...