It is my understanding that for the modular 5.4, supercharging is considerably easier, using available, largely bolt on parts. Most parts produced for the 4.6 sibling will be suitable.
Be careful with which 5.4 you've got. The lower compression ones will be more suitable.
There will need to be computer adjustments, Dimi has access to a program which assists the 5.4's N/A breathing, so it might be a starting point.
Aside from being committed to using 98 octane fuel, I can't think of a reason why not.
The basic 5.4 is the same capacity as the Ford GT's supercharged engine, but the details are (unfortunately) very different.
Good luck!