Yes...
The lubrification system is an half bath, basically the secondary shaft stands fully under oil and brings lubrication by splashing the primeshaft.
Inverting this :
The primeshaft will be then under oil and the secondary over. The primeshaft pinions are smaller than those standing on the secondary, so the splashing capacities will be reduced.
Also it means that the shaft handling the more torque (secondary) will be out of oil, hence the bearings will meet very poor lubrification.
Also expect a lot of leaks, from the rear cover, and into the clutch.
Greetings
Stephane