I recall that there were issues with the Caddie 8-6-4. That is not to say there aren't some that have tons of miles, but there were issues with the system. I have had several high mileage Fiats, but wouldn't suggest those as any stellar auto...but I like them, maybe the fact that I have been a tech since 1969 makes them easier to deal with than someone that relies on service persons. My understanding of the systems issues had to do with the "canceling" procedure. I believe that it was set up so that it didn't cancel the same cylinders so as to keep wear among them fairly equal. It may have been cut because it didn't help meet CAFE standards, but in this area they were notorious for malfunctioning.
Those were designed to cancel injector pulse if I recall correctly, I think the newer systems deactivate the valve train on different cylinders.
In the gas crunch of the 70s I remember Crower( of cam fame) offering a kit not unlike the one described that was used during WW2. It basically removed the piston/rods on 2 inner and 2 outer cylinders on opposite banks and effectively made it a V4. The problem I saw with it was that they were only made for large barges...Caddies,Toronados,Lincolns,etc... So the decrease in power was quite dramatic because of the cars' mass. JC Whitney even offered them for awhile...but that was probably after they tanked in early marketing and needed to unload some of them. They were fairly elaborate kits, including items to retain the lifters in their passages with springs when the pushrods were removed. The kit was expensive and the labor was more. Then, if you wanted to sell it or convert back when the gas flowed again...more expense. Interesting concept but fell a little short in application.